Fig. 4.

Facilitation of anandamine signaling, but not antagonism of CB₁ receptors, attenuates repeated restraint-induced increase in basal corticosterone secretion. Mean (±SEM) corticosterone (CORT; ng/mL) concentrations in circulation under basal conditions in unstressed controls (CTL), and after 9 days of repeated restraint in animals bearing daily systemic injections of vehicle (VEH), AM251, URB597, or AM404. *P < 0.05 vs. unstressed controls; ^#P < 0.05 vs. vehicle- and AM251-treated animals (n = 5/group).