Fig. 5.

Antagonism of CB₁ receptors, but not facilitation of anandamide signaling, blocks repeated restraint-induced decline in corticosterone responses. Mean (±SEM) corticosterone (CORT; ng/mL) concentrations in circulation on first (Acute) and last (Repeat) day of restraint at 30 min of exposure in animals bearing acute systemic injections of vehicle (VEH), CB₁ receptor antagonist AM251, anandamide hydrolysis inhibitor URB597, or anandamide uptake/hydrolysis inhibitor AM404. *P < 0.05 vs. acute counterpart (n = 5/group).