Table 1.
Dosage-balanced ohnologs and Down Syndrome-related genes on chromosome 21
| Ensembl id | Gene symbol | Full name | Reference |
| ENSG00000188992 | LIPI | Lipase, member I | |
| ENSG00000185272 | RBM11 | RNA binding motif protein 11 | |
| ENSG00000155313 | USP25 | Ubiquitin specific peptidase 25 | |
| ENSG00000154640 | BTG3 | BTG family, member 3 | |
| ENSG00000154645 | CHODL | Chondrolectin | |
| ENSG00000154654 | NCAM2 | Neural cell adhesion molecule 2 | |
| ENSG00000154721 | JAM2 | Junctional adhesion molecule 2 | |
| ENSG00000142192 | APP | Amyloid β (A4) precursor protein | 37 |
| ENSG00000156253 | RWDD2B | RWD domain containing 2B | |
| ENSG00000156256 | USP16 | Ubiquitin specific peptidase 16 | |
| ENSG00000156273 | BACH1 | BTB and CNC homology 1 | 37 |
| ENSG00000171189 | GRIK1 | Glutamate receptor, ionotropic, kainate 1 | |
| ENSG00000156299 | TIAM1 | T-cell lymphoma invasion and metastasis 1 | |
| ENSG00000142168 | SOD1 | Superoxide dismutase 1 | 37 |
| ENSG00000159082 | SYNJ1 | Synaptojanin 1 | 37 |
| ENSG00000159110 | IFNAR2 | Interferon receptor 2 | 37 |
| ENSG00000142188 | TMEM50B | Transmembrane protein 50B | |
| ENSG00000159200 | DSCR1 | Down syndrome critical region gene 1 | 36, 37 |
| ENSG00000159212 | CLIC6 | Chloride intracellular channel 6 | |
| ENSG00000159216 | RUNX1 | Runt-related transcription factor 1 | |
| ENSG00000159263 | SIM2 | Single-minded homolog 2 | 36 |
| ENSG00000157540 | DYRK1A | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 36, 37 |
| ENSG00000157542 | GIRK2 | Potassium inwardly-rectifying channel, subfamily J, member 6 | 36 |
| ENSG00000157554 | ERG | V-ets erythroblastosis virus E26 oncogene homolog | 37 |
| ENSG00000157557 | ETS2 | V-ets erythroblastosis virus E26 oncogene homolog 2 | 37 |
| ENSG00000185658 | BRWD1 | Bromodomain and WD repeat domain containing 1 | |
| ENSG00000205581 | HMG14 | High-mobility group nucleosome binding domain 1 | 37 |
| ENSG00000157578 | LCA5L | Leber congenital amaurosis 5-like | |
| ENSG00000185437 | SH3BGR | SH3 domain binding glutamic acid-rich protein | |
| ENSG00000183778 | B3GALT5 | β-1,3-galactosyltransferase 5 | |
| ENSG00000171587 | DSCAM | Down syndrome cell adhesion molecule | 37 |
| ENSG00000182240 | BACE2 | β-site APP-cleaving enzyme 2 | 37 |
| ENSG00000183421 | RIPK4 | Receptor-interacting serine-threonine kinase 4 | |
| ENSG00000157617 | C2CD2 | C2 calcium-dependent domain containing 2 | |
| ENSG00000160179 | ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | |
| ENSG00000160185 | UBASH3A | Ubiquitin associated and SH3 domain containing, A | |
| ENSG00000160190 | SLC37A1 | Solute carrier family 37, member 1 | |
| ENSG00000160199 | PKNOX1 | PBX/knotted 1 homeobox 1 | 37 |
| ENSG00000184900 | SUMO3 | SMT3 suppressor of mif two 3 homolog 3 | |
| ENSG00000197381 | ADARB1 | Adenosine deaminase, RNA-specific, B | |
| ENSG00000173638 | SLC19A1 | Solute carrier family 19, member 1 | |
| ENSG00000183570 | PCBP3 | Poly(rC) binding protein 3 | |
| ENSG00000160305 | DIP2A | DIP2 disco-interacting protein 2 homolog A | |
| ENSG00000160307 | S100B | S100 calcium binding protein B | 37 |
Where a reference is provided, those genes were previously reported as candidate DS genes. Genes in bold are not dosage-balanced ohnologs.