Table 5.

Perception of risk level of four research scenarios

	DD Participants (n=80)						Controls (n=98)
Level of Risk	Survey 1 (n=80)	Survey 2 (n=80)	Survey 3 (n=76)	Survey 1v2	Survey 2v3	Survey 1v3	Survey 1 (n=91)	Survey 2 (n=89)	Survey 3 (n=93)	Survey 1v2	Survey 2v3	Survey 1v3
Lumbar Puncture	%	%	%	p-value	p-value	p-value	%	%	%	p-value	p-value	p-value
Minimal Risk or Less	20	46	30	0.002	0.05	0.04	23	30	25	0.41	0.15	0.33
Minor Increase Over Minimal Risk	42	29	29				40	30	44
Moderate Risk	34	24	40				36	38	28
High Risk	4	1	1				1	2	3
New Drug RCT	%	%	%	p-value	p-value	p-value	%	%	%	p-value	p-value	p-value
Minimal Risk or Less	28	26	18	0.08	0.63	0.26	30	32	32	0.54	0.04	0.26
Minor Increase Over Minimal Risk	38	41	51				41	35	50
Moderate Risk	32	31	29				29	34	19
High Risk	3	1	1				0	0	0
Vaccine	%	%	%	p-value	p-value	p-value	%	%	%	p-value	p-value	p-value
Minimal Risk or Less	3	1	0	0.26	0.25	0.84	2	5	5	0.68	0.82	0.86
Minor Increase Over Minimal Risk	9	17	9				18	16	17
Moderate Risk	58	63	62				54	51	52
High Risk	31	19	29				25	29	25
Gene Transfer	%	%	%	p-value	p-value	p-value	%	%	%	p-value	p-value	p-value
Minimal Risk or Less	3	1	0	0.15	0.57	0.52	2	1	3	0.59	0.19	0.57
Minor Increase Over Minimal Risk	8	1	1				9	12	7
Moderate Risk	32	39	40				37	31	39
High Risk	58	58	59				52	56	51