Table 1.
p53 Gene Sequencing of Melanoma Lines
| |
|
Mutation or polymorphisma |
|
||
|---|---|---|---|---|---|
| Tumor cell line | p53 gene | Exon | Coding sequence | Amino acid change | Comment |
| 1890 | Wild-type | ||||
| 1833 | Wild-type | ||||
| 2436 | Wild-type | ||||
| 624 | Mutant | 8 | bp 825, T > G | C275W | DNA-binding region |
| 526 | Mutant | 5 | bp 389, T > C | L130P | DNA-binding region |
| 4 | bp 215, G > C | R72P | Polymorphism | ||
| 2081 | Wild-type | ||||
| 2098 | Wild-type | ||||
| 2224 | Wild-type | 4 | bp 215, G > C | R72P | Polymorphism, heterozygous |
| 1861 | Mutant | 5 | bp 389, T > C | L130P | DNA-binding region |
| 4 | bp 215, G > C | R72P | Polymorphism | ||
| 2207 | Wild-type | ||||
| 1994 | Wild-type | ||||
| 2218 | Wild-type | ||||
| 2319 | Wild-type | ||||
a
Mutations or polymorphisms indicated are homozygous unless otherwise noted.