Table 2.
Table 2a: Anatomical Locations of the Planned Comparisons during Happiness Paradigm | ||||||||
---|---|---|---|---|---|---|---|---|
MNI coordinates |
||||||||
Region | Side | X | Y | Z | K | T | z | p |
Happy pictures | ||||||||
Clomipramine < Washout | ||||||||
vmPFC (BA11) | R | 28 | 42 | −8 | 26 | 3.38 | 2.74 | 0.003 |
Insula | R | 40 | 14 | 8 | 77 | 3.43 | 2.77 | 0.003 |
R | 32 | −26 | 10 | 67 | 2.76 | 2.35 | 0.009 | |
Anterior Cingulate (BA24) | R | 4 | 28 | 22 | 29 | 3.05 | 2.54 | 0.005 |
Anterior Cingulate (BA32) | L | −8 | 42 | 14 | 80 | 3.85 | 3 | 0.001 |
Caudate body | L | −16 | −14 | 26 | 157 | 4.11 | 3.13 | 0.001 |
R | 16 | −14 | 24 | 132 | 5.5 | 3.74 | <0.001 | |
medial PFC (BA10) | L | −16 | 42 | 14 | 32 | 3.19 | 2.63 | 0.004 |
Putamen | L | −14 | 2 | 10 | 66 | 2.34 | 2.07 | 0.019 |
Table 2b: Anatomical Locations of the Planned Comparisons during Fear Paradigm | ||||||||
---|---|---|---|---|---|---|---|---|
MNI coordinates |
||||||||
Region | Side | X | Y | Z | K | T | z | p |
Fear pictures | ||||||||
Clomipramine < Washout | ||||||||
vLPFC (BA47) | L | −32 | 16 | −2 | 24 | 3.22 | 2.61 | 0.005 |
DLPFC (BA46) | L | −46 | 36 | 16 | 30 | 3.25 | 2.62 | 0.004 |
Amygdala | L | −28 | −8 | −12 | 12 | 2.83 | 2.37 | 0.009 |
Insula | L | −44 | −16 | 18 | 97 | 5.06 | 3.49 | <0.001 |
R | 38 | 0 | 14 | 186 | 6.46 | 3.97 | <0.001 | |
Parahippocampal Gyrus | R | 20 | −34 | −14 | 184 | 6.2 | 3.89 | <0.001 |
DLPFC (BA9) | R | 42 | 22 | 36 | 47 | 2.69 | 2.28 | 0.011 |
L | −52 | 2 | 36 | 24 | 3.62 | 2.83 | 0.002 | |
Thalamus | R | 20 | −14 | 6 | 253 | 4.31 | 3.17 | <0.001 |
Putamen | R | 28 | −16 | −4 | 114 | 4.65 | 3.32 | <0.001 |
Neutral pictures | ||||||||
Clomipramine > Washout | ||||||||
vmPFC (BA11) | L | −24 | 44 | −6 | 8 | 2.22 | 1.96 | 0.025 |
Clomipramine < Washout | ||||||||
Anterior Cingulate (BA24) | L | −4 | 22 | 22 | 24 | 2.55 | 2.19 | 0.014 |
Amygdala | R | 28 | −8 | −14 | 65 | 3.58 | 2.81 | 0.002 |
Table 2c: Anatomical Locations of the Planned Comparisons during Anger Paradigm | ||||||||
---|---|---|---|---|---|---|---|---|
MNI coordinates |
||||||||
Region | Side | X | Y | Z | K | T | z | p |
Anger pictures | ||||||||
Clomipramine < Washout | ||||||||
vLPFC (BA47) | R | 36 | 30 | −2 | 22 | 3.49 | 2.8 | 0.003 |
R | 26 | 16 | −12 | 42 | 3.29 | 2.7 | 0.004 | |
R | 44 | 18 | 2 | 47 | 3.03 | 2.5 | 0.006 | |
L | −32 | 16 | −12 | 72 | 8.49 | 4.6 | <0.001 | |
DLPFC (BA46) | R | 42 | 36 | 16 | 53 | 4.15 | 3.2 | 0.001 |
Amygdala | R | 28 | −4 | −16 | 61 | 3.02 | 2.5 | 0.006 |
Insula | L | −32 | 16 | −10 | 529 | 6.62 | 4.1 | <0.001 |
L | −50 | −38 | 20 | 66 | 2.73 | 2.3 | 0.01 | |
R | 38 | 12 | −10 | 82 | 4.78 | 3.4 | <0.001 | |
R | 32 | 14 | 12 | 524 | 4.34 | 3.3 | <0.001 | |
R | 42 | −40 | 18 | 86 | 3.82 | 3 | 0.001 | |
Anterior Cingulate (BA24) | R | 4 | 30 | 24 | 35 | 3.61 | 2.9 | 0.002 |
L | −2 | 32 | 18 | 41 | 2.82 | 2.4 | 0.008 | |
Anterior Cingulate (BA32) | R | 6 | 32 | 26 | 35 | 4.37 | 3.3 | 0.001 |
L | −2 | 32 | 22 | 35 | 2.44 | 2.1 | 0.016 | |
Parahippocampal Gyrus | R | 16 | −48 | 2 | 143 | 3.09 | 2.6 | 0.005 |
L | −20 | −34 | −8 | 270 | 3 | 2.5 | 0.006 | |
Hippocampus | L | −26 | −36 | −4 | 9 | 2.73 | 2.3 | 0.01 |
DLPFC (BA9) | R | 4 | 46 | 28 | 37 | 3.45 | 2. 8 | 0.003 |
R | 34 | 20 | 34 | 129 | 3.31 | 2.7 | 0.003 | |
Thalamus | R | 8 | −22 | −2 | 621 | 5.02 | 3.5 | <0.001 |
L | −18 | −22 | 0 | 282 | 6.72 | 4.1 | <0.001 | |
Caudate body | R | 8 | 12 | 8 | 173 | 6.02 | 3.9 | <0.001 |
Caudate head | R | 8 | 18 | 6 | 169 | 6.31 | 4.0 | <0.001 |
L | −8 | 6 | 0 | 64 | 2.65 | 2.3 | 0.011 | |
Putamen | R | 22 | −2 | 0 | 552 | 5.4 | 3.7 | <0.001 |
L | −18 | 4 | −8 | 256 | 4.33 | 3.2 | 0.001 | |
Neutral pictures | ||||||||
Clomipramine < Washout | ||||||||
Insula | L | −40 | −12 | 6 | 122 | 4.72 | 3.4 | <0.001 |
R | 40 | −20 | 6 | 72 | 4.56 | 3.3 | <0.001 |
vmPFC: ventromedial prefrontal cortex; R, right; L, left; BA, Brodmann area; Coordinates correspond to the stereotaxic array of Montreal Neurologic Institute; K: cluster size; PFC, prefrontal cortex
vLPFC: ventrolateral prefrontal cortex DLPFC: dorsolateral prefrontal cortex; R, right; L, left; BA, Brodmann area; Coordinates correspond to the stereotaxic array of Montreal Neurologic Institute; K: cluster size; vmPFC, ventromedial prefrontal cortex
vLPFC: ventrolateral prefrontal cortex DLPFC: dorsolateral prefrontal cortex; Coordinates correspond to the stereotaxic array of Montreal Neurologic Institute; BA, Brodmann area; R, right; L, left; K: cluster size