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. Author manuscript; available in PMC: 2010 Jun 22.
Published in final edited form as: Channels (Austin). 2008 May 24;2(3):159–160. doi: 10.4161/chan.2.3.6188

Figure 1. Role of the HLFY motif in the formation of functional NMDA receptors.

Figure 1

(A) Currents elicited with 1 mM glutamate and 1 mM glycine during whole-cell patch-clamp recordings from HEK293 cells expressing indicated combinations of NMDA receptor subtypes are shown (holding potential at −60 mV). (B) Bar graph representing the mean peak current amplitudes ± SEM of evoked whole-cell currents. The numbers of cells responding to agonists out of the total number of recorded cells are shown above the columns. Data from cells expressing NR1-1a/NR2B preM4/NR2B M4-0 were pooled together from two separate experiments (#). (C) The amino acid sequence of NR2B M4-0 is depicted. Grey color indicates the M4 domain.