Table 1.
Sample Characteristics at Study Entrya
| All N=124 | CBT N=17 | Med N=14 | Comb N=93 | P | |
|---|---|---|---|---|---|
| Females (%) | 77.4 | 94.1 | 92.9 | 72.0 | 0.05 |
|
| |||||
| White (%) | 79.8 | 70.6 | 85.7 | 80.7 | 0.54 |
|
| |||||
| Age, mean (SD) | 15.7 (1.5) | 15.7 (1.5) | 15.6 (1.4) | 15.7 (1.6) | 0.98 |
|
| |||||
| Diagnosis (%) | |||||
| MDD only | 85.5 | 94.1 | 92.9 | 82.8 | 0.34 |
| DD only | 0.8 | 0 | 0 | 1.1 | 0.85 |
| Both | 10.5 | 0 | 7.1 | 12.9 | 0.11 |
| D-NOS | 3.2 | 5.9 | 0 | 3.2 | 0.66 |
|
| |||||
| Comorbidity (%) | |||||
| Anxiety | 54.0 | 23.5 | 28.6 | 63.4 | 0.001 |
| ADHD | 21.0 | 11.8 | 14.3 | 23.7 | 0.44 |
| ODD/CD | 15.3 | 0.0 | 35.7 | 15.1 | 0.02 |
|
| |||||
| History of Multiple Suicide attempts N(%) | 54(43.6) | 6(35.3) | 4(28.6) | 44(47.3) | 0.32 |
|
| |||||
| CDRS-R, mean (SD) | 50.4 (12.6) | 46.9 (14.7) | 43.4 (11.1) | 52.1 (12.0) | 0.01 b Comb>Med, CBT |
|
| |||||
| MADRS,mean(SD) | 24.8 (11.7) | - c | 22.4 (12.8) | 25.2(11.5) | 0.08 b |
|
| |||||
| BDI, mean (SD) | 22.8 (13.2) | 18.1 (13.7) | 20.2 (10.3) | 23.9 (13.4) | 0.40 b |
|
| |||||
| CGI-S, mean (SD) | 4.5 (0.9) | 4.0 (0.8) | 2.8 (1.4) | 4.6 (0.9) | 0.003 b Comb>Med, CBT |
|
| |||||
| C-GAS, mean (SD) | 48.4(11.1) | 54.9(15.1) | 57.6(8.1) | 45.9 (9.5) | 0.0003 b Comb<Med, CBT |
|
| |||||
| SAS, mean (SD) | 57.1 (14.4) | 50.3 (13.2) | 57.1 (9.3) | 58.0 (15.1) | 0.12 b |
|
| |||||
| SSI, mean (SD) | 6.3 (7.7) | 5.0 (6.0) | 3.9 (6.0) | 6.9 (8.2) | 0.14 b |
Abbreviations: CBT: cognitive behavioral therapy; Med: antidepressant pharmacotherapy; Comb: combination of both CBT and antidepressant pharmacotherapy; MDD: major depressive disorder; DD: dysthymic disorder; D-NOS: depressive disorder not otherwise specified; CDRS-R: Child Depression Rating Scale-Revised; Montgomery-Asberg Depression Rating Scake; BDI: Beck Depression Inventory; CGI-S: Clinical Global Impressions-Severity; C-GAS: Children Global Assessment Scale; SAS: Social Adjustment Scale (self-report); SSI: Scale for Suicidal Ideation
a
Raw (unadjusted) scores from rating scales
b
Adjusted for site
c
The MADRS was completed by the pharmacotherapist (in Med and Comb only).