Table 2.
Depressive Symptoms Ratings during Combined CBT/Medication Treatment in TASA and Other Multisite Studies in Adolescent Depression
| Study | TASA | TADS5,6 | ADAPT22 | TORDIA7 |
|---|---|---|---|---|
| Design | patient choice | randomized | randomized | randomized |
| Na | 93b | 107 | 105 | 166 |
|
| ||||
| Females | 72% | 56% | 75% | 70% |
|
| ||||
| Age, yr, mean (SD) | 15.7 (1.6) | 14.6 (1.5) | 14.0 (1.5) | 16.0 (1.5) |
|
| ||||
| Diagnosis | Major depressive (96% of the sample) | Major depressive disorder | Major depressive disorder or 4 depressive symptoms | Major depressive disorder |
|
| ||||
| Suicidal history | Suicide attempt in the 90 days prior to study entry | Youths at high-risk for suicidality were excluded, but 29% of the participants had significant suicidal ideation | About half of the sample had history of suicidal behavior | 58% of the participants had clinically significant suicidal ideation |
|
| ||||
| Comorbidity | 68% | 52% | 88% | 52% |
|
| ||||
| Drop-out by Week 12 | 15% | 14% | 11% | 16% |
| Drop-out by Week 24a | 29% | 20% | 17% | -e |
|
| ||||
| CDRS-Rc | ||||
| Baseline, mean (SD) | 49.6 (12.3) | 60.8 (6.2) | 58.9 (10.5)e | 59.2 (11.0) |
| Week 12, mean (SD) | 38.3 (8.0) | 33.6 (8.6) | 42.5 (16.8)e | 36.9 (13.9) |
| Week 24,e mean (SD) | 27.0 (10.1) | 30.0 (8.1) | 36.4 (15.3)e | -e |
| CGI-I-Response ratef | ||||
| Week 12 | 58.0% | 71.0% | 41.6% | 59.0% |
| Week 24e | 72.2% | 77.6% | 53.1% | -h |
| Remission rateg | ||||
| Week 12 | 32.5% | 37% | -h | 31% |
| Week 24e | 50.0% | 56% | -h | -h |
|
| ||||
| C-GASc | ||||
| Baseline, mean (SD) | 49.3 (10.4) | 50.0 (7.5) | 41.6 (6.0) | 50.6 (7.7) |
| Week 12, mean (SD) | 61.0 (8.0) | 66.6 (11.9) | 52.1 (14.3) | 65.1 (11.8) |
| Week 24,e mean (SD) | 72.6 (11.4) | -h | 57.2 (16.4) | -h |
|
| ||||
| Incidence of suicidal attemptsi | ||||
| By Week 12 | 12.9% | 2.8% | 6.9% | 6.0% |
| By Week 24e | 15.1% | 3.7% | 7.1% | -h |
Abbreviations: TASA: Treatment of Adolescent Suicide Attempters; TADS: Treatment for Adolescents with Depression Study; ADAPT: Antidepressant and Psychotherapy Trial; TORDIA: Treatment of Resistant Depression in Adolescents; CDRS-R: Child Depression Rating Scale-Revised; CGI-I: Clinical Global Impressions-Improvement; C-GAS: Children Global Assessment Scale
Combined treatment group only
86 chose treatment and 7 were randomized
Adjusted means based on intent-to-treat regression analyses, except for ADAPT (see foot-note d)
dActual scores. N=104 at baseline, N=100 at week 12 and N=98 at week 28.
Week 28 for ADAPT
Response: score of 1 (very much improved) or 2 (much improved) on the CGI-I, with last observation carried forward
Remission: CDRS-R ≤28, with last observation carried forward.
Data not available
Actual suicide attempt (i.e., excluding aborted or interrupted attempts)