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Hot spots detected on the surface of GCase using FTMap. Simulations were performed on (A) apo GCase (2NT1) (B) glycerol-bound GCase (2NSX chain A) and (C) IFG-bound GCase (2NSX chain B). Although differences in the location of consensus sites are evident (cluster representatives colored in cyan) two hot spot regions, circled in (A) are conserved in all three structures.
