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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Chem Biol Interact. 2010 Feb 13;187(1-3):191–198. doi: 10.1016/j.cbi.2010.02.015

Fig. 3.

Fig. 3

Representative EEG traces for Control, DFP, DFP then 2-PAM, and DFP then Pro-2-PAM treated guinea pigs. Each block shown is 6 h of EEG recording, with a continuous trace to 24 h for each treatment. Animals received pyridostigmine bromide (0.026 mg/kg, i.p.) then 20 min later DFP (8 mg/kg, s.c; black circle) followed at 1 min by atropine methylbromide (2 mg/kg) and 1.5 human auto-injector equivalents of each oxime (13 mg/kg, i.m.). 2-PAM was injected at 1 min post-DFP exposure, whereas pro-2-PAM treatment was delayed in this example by 15 min. The 19–24 h EEG panels show the efficacy of pro-2-PAM, but not 2-PAM, to alleviate SE.