Table 3.

Assessing the impact of the chosen prior distribution on the operating characteristics presented for Scenario A in Table 1. All percentages are multiplied by 100. All combinations have a true DLT probability within 10 points of the target probability p^* = 0.20, except combinations (1,1), (2,1), and (4,4).

					% of Simulations Selected as MTC				Mean % of Subjects Assigned
	Prior Parameters				Dose of Agent A
Scenario	μ	ω	σ2	Dose of Agent B	1	2	3	4	1	2	3	4
A1	4.79	6.78	10	1	2	2	4	3	8	3	3	2
	6.32	6.32		2	1	5	10	25	2	8	7	18
	6.32	6.32		3	16	8	7	2	9	7	10	3
				4	2	4	3	5	1	3	3	12
A2	3.00	6.98	10	1	0	1	2	3	6	3	3	2
	6.32	6.32		2	2	6	8	6	3	10	7	4
	6.32	6.32		3	5	9	10	5	5	8	12	6
				4	4	5	6	5	3	4	6	18
A3	4.79	6.78	5	1	1	3	4	3	8	3	3	2
	4.47	4.47		2	3	7	9	23	2	9	8	17
	4.47	4.47		3	16	8	6	1	10	7	10	2
				4	2	4	4	4	1	3	4	11
A4	3.00	6.98	5	1	0	2	4	2	5	3	3	2
	4.47	4.47		2	3	9	11	7	4	10	8	4
	4.47	4.47		3	5	13	12	6	5	9	13	5
				4	6	6	5	7	3	4	6	16
A5	4.79	6.78	15	1	2	2	3	4	7	3	3	2
	7.75	7.75		2	2	5	9	24	2	8	7	17
	7.75	7.75		3	17	8	8	2	10	7	11	3
				4	2	4	4	5	1	3	4	13
A6	3.00	6.98	15	1	0	2	2	3	6	3	3	2
	7.75	7.75		2	3	11	8	7	3	10	8	4
	7.75	7.75		3	5	12	14	8	4	8	13	6
				4	6	6	7	6	3	4	6	18