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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Ageing Res Rev. 2010 Jan 28;10(2):181–190. doi: 10.1016/j.arr.2010.01.002

Figure 1.

Figure 1

Bird fibroblasts are more resistant to lethal stress than mouse or rat fibroblasts derived from wild-caught animals. Note the lack of overlap between values for bird cells and mean levels for mouse and rat cells. Values shown are LD50’s, corresponding to the dose of the toxic agent that results in death of 50% of the cells; note that the scale is logarithmic. Each symbol represents a different individual bird with one bird from each of 19 different species. All cell lines were derived using 20% O2, cryopreserved, and then expanded for two passages at 3% O2 before testing in 3% O2. (M) and (R) symbols indicate mean LD50 values detected in a previous set of experiments (Harper et al., 2007) using the same methods. MMS = methyl methanesulfonate. Units for LD50 are μM (cadmium and H2O2) and mM (paraquat and MMS).