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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Ageing Res Rev. 2010 Jan 28;10(2):181–190. doi: 10.1016/j.arr.2010.01.002

Figure 2.

Figure 2

Legend: Dog fibroblasts are typically more resistant to lethal stress than mouse or rat fibroblasts from wild-caught individuals. There is little to no overlap in the observed values for dog cell lines with mean values of mouse and rat cells. Values shown are LD50’s, corresponding to the dose of the toxic agent that results in death of 50% of the cells; note that the scale is logarithmic only for the cadmium panel. Each symbol represents an individual dog, representing a mixture of purebred and mixed-breed animals (21 – 36 dogs per panel). The dog cell lines were derived using 3% O2, cryopreserved, and then expanded for two passages at 3% O2 before testing in 3% O2. (M) and (R) symbols indicate mean LD50 values detected in a previous set of experiments (Harper et al., 2007) using the same methods, except that the O2 tension was 20%. Pilot studies using mouse cell lines have indicated no consistent effect of initial O2 tension on LD50 values, regardless of test condition (not shown). Units for LD50 are μM (cadmium and H2O2) and J/m2 (UV).