Table 4.
Association of select components of the MeDi and the MeDi score with a-MCI and na-MCI
| Variable | Controls | Cases | ORa | 95% CIa | P | p for trend | ORb | 95% CIb | P | p for trend |
|---|---|---|---|---|---|---|---|---|---|---|
| a-MCI | ||||||||||
| Vegetables (without legumes) | ||||||||||
| ≤109.6 g/day | 341 (31.9) | 54 (44.3) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 109.7-191.0 g/day | 364 (34.0) | 39 (32.0) | 0.70 | 0.46-1.07 | 0.10 | − | 0.66 | 0.42-1.02 | 0.06 | − |
| >191.0g/day | 365 (34.1) | 29 (23.8) | 0.57 | 0.38-0.90 | 0.02 | 0.04 | 0.59 | 0.37-0.95 | 0.03 | 0.05 |
| MUFA:SFA ratio | ||||||||||
| ≤0.955 | 353 (33.0) | 50 (41.0) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 0.956-1.123 | 358 (33.5) | 35 (28.7) | 0.63 | 0.40-0.97 | 0.03 | − | 0.64 | 0.41-1.02 | 0.06 | − |
| >1.123 | 359 (33.6) | 37 (30.3) | 0.60 | 0.39-0.93 | 0.02 | 0.03 | 0.63 | 0.40-1.00 | 0.05 | 0.07 |
| (MUFA + PUFA):SFA ratio | ||||||||||
| ≤1.415 | 346 (32.3) | 51 (41.8) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 1.416-1.705 | 353 (33.0) | 42 (34.4) | 0.81 | 0.53-1.22 | 0.31 | − | 0.86 | 0.56-1.34 | 0.51 | − |
| >1.705 | 371 (34.7) | 29 (23.8) | 0.48 | 0.30-0.76 | 0.002 | 0.007 | 0.49 | 0.30-0.80 | 0.004 | 0.01 |
| MeDi score Ic | ||||||||||
| 0-3 | 262 (24.5) | 33 (27.0) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 4-5 | 463 (43.3) | 60 (49.2) | 1.07 | 0.69-1.66 | 0.75 | − | 1.01 | 0.64-1.59 | 0.98 | − |
| 6-9 | 345 (32.2) | 29 (23.8) | 0.79 | 0.48-1.30 | 0.35 | 0.38 | 0.74 | 0.44-1.25 | 0.26 | 0.39 |
| MeDi score 2c | ||||||||||
| 0-3 | 265 (24.8) | 36 (39.5) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 4-5 | 458 (42.8) | 56 (45.9) | 0.93 | 0.60-1.42 | 0.73 | − | 0.91 | 0.58-1.43 | 0.68 | − |
| 6-9 | 347 (32.4) | 30 (24.6) | 0.74 | 0.46-1.21 | 0.23 | 0.46 | 0.73 | 0.44-1.22 | 0.23 | 0.47 |
| na-MCI | ||||||||||
| Vegetables (without legumes) | ||||||||||
| ≤109.6 g/day | 341 (31.9) | 16 (39.0) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 109.7-191.0 g/day | 364 (34.0) | 9 (22.0) | 0.60 | 0.29-1.29 | 0.19 | − | 0.52 | 0.24-1.16 | 0.11 | − |
| > 191.0 g/day MUFA:SFA ratio | 365 (34.1) | 16 (39.0) | 1.41 | 0.73-2.74 | 0.31 | 0.09 | 1.18 | 0.58-2.39 | 0.64 | 0.13 |
| ≤0.955 | 353 (33.0) | 8 (19.5) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 0.956-1.123 | 358 (33.5) | 19 (46.3) | 2.57 | 1.21-5.50 | 0.01 | − | 2.75 | 1.22-6.22 | 0.01 | − |
| >1.123 | 359 (33.6) | 14 (34.1) | 1.74 | 0.78-3.87 | 0.18 | 0.05 | 1.70 | 0.71-4.08 | 0.23 | 0.04 |
| (MUFA + PUFA):SFA ratio | ||||||||||
| ≤1.415 | 346 (32.3) | 14 (34.1) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 1.416-1.705 | 353 (33.0) | 17 (41.5) | 1.37 | 0.71-2.65 | 0.35 | − | 1.57 | 0.78-3.17 | 0.21 | − |
| >1.705 | 371 (34.7) | 10 (24.4) | 0.73 | 0.34-1.54 | 0.41 | 0.22 | 0.63 | 0.27-1.47 | 0.29 | 0.07 |
| MeDi score Ic | ||||||||||
| 0-3 | 262 (24.5) | 11 (26.8) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 4-5 | 463 (43.3) | 16 (39.0) | 0.95 | 0.47-1.94 | 0.90 | − | 1.03 | 0.47-2.22 | 0.95 | − |
| 6-9 | 345 (32.2) | 14 (34.1) | 1.28 | 0.61-2.69 | 0.51 | 0.65 | 1.41 | 0.63-3.16 | 0.40 | 0.60 |
| MeDi score 2c | ||||||||||
| 0-3 | 265 (24.8) | 11 (26.8) | 1.00 | reference | − | − | 1.00 | reference | − | − |
| 4-5 | 458 (42.8) | 17 (41.5) | 1.05 | 0.52-2.12 | 0.89 | − | 1.19 | 0.55-2.54 | 0.66 | − |
| 6-9 | 347 (32.4) | 13 (31.7) | 1.21 | 0.57-2.56 | 0.63 | 0.87 | 1.37 | 0.60-3.10 | 0.45 | 0.75 |
Figures in parentheses indicate percentages.
a
Odds ratio (95% confidence intervals) adjusted for age, years of education, total energy (as continuous variables), and sex. All models were adjusted with propensity weights to take into account potential nonparticipation bias. There were 122 cases with a-MCI and 41 cases with na-MCI.
b
Adjusted for age, years of education, total energy (continuous variables), sex, ApoE ε4 (ε4+ vs. ε4−), stroke, coronary heart disease, and depressive symptoms.
c
Fat intake was determined from the MUFA:SFA ratio for MeDi score 1, and from the (MUFA + PUFA):SFA ratio for MeDi score 2.