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. 2010 Apr 21;107(19):8557–8562. doi: 10.1073/pnas.1000059107

Fig. 2.

Fig. 2.

Knockdown in the expression of CYP6BQ9 in T. castaneum QTC279 strain reduced its resistance to deltamethrin. (A) The mRNA levels of CYP6BQ9 were quantified by qRT-PCR at 5 days after dsRNA injection. The relative mRNA levels were shown as a ratio in comparison with the levels of rp49 mRNA. The data shown are mean + SEM (n = 3). Statistical significance of the gene expression between two samples was calculated using Student's t test. **P < 0.01. (B) Dose-response curves (log dose versus mortality on a probit scale) for T. castaneum adults exposed to deltamethrin. Bioassays were performed 5 days after dsRNA injection. Lab-S (○◯), a susceptible strain; QTC279 (▽), a deltamethrin resistant strain; QTC279-CYP6BQ9 RNAi (●), QTC279 strain injected with CYP6BQ9 dsRNA; and QTC279-malE RNAi (▼), QTC279 strain injected with malE dsRNA as a control were exposed to various doses of deltamethrin, and the mortality was recorded and graphed.