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. 2010 Apr 26;107(19):8788–8793. doi: 10.1073/pnas.1003428107

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Fig. 6. — Mitochondrial metabolism is required for oncogenic Kras-driven mouse lung adenocarcinoma. (A) Western blot analysis of TFAM, cytochrome c oxidase subunit I protein (COXI), and α-TUBULIN in lung lysates and (B) histology of LSL-Kras G12D^fl/+ and LSL-Kras G12D^fl/+ Tfam^fl/fl lungs 12-weeks post treatment with intratracheal instillation of Cre-recombinase. (Scale bars, 1 cm.) (C and D) Tumor loads and number of lesions per area of lung tissue in LSL-Kras G12D^fl/+ and LSL-Kras G12D^fl/+ Tfam^fl/fl mice. Bars represent the mean ± SE (n = 6 animals). *P < 0.05. (E) Ki67 staining (proliferative index) of the LSL-Kras G12D^fl/+ and LSL-Kras G12D^fl/+ Tfam^fl/fl mice lungs. Bars represent the mean ± SE (n = 6 animals). *P < 0.05.