Fig. 4.

Modulating 15-epi-LxA₄ with ASA^low dampens inflammation in E^rvs. ASA^low (75 mg/d for 10 d, data represented by red line) elevated 15-epi-LxA₄ in the blister fluids of 16 volunteers (A) as well as ALX expression on total blister leukocyte (B), PMN (C), and monocytes (D) compared with controls (black line). This elevation in endogenous 15-epi-LxA₄/ALX was associated with reduced blister fluid IL-β (E) and IL-8 (F) as well as blister total leukocyte (G), PMN (H), and monocyte numbers (I). Data are presented as mean ± SEM; *P < 0.05 represent differences after 24 h in cantharidin-induced skin blister inflammatory parameters in E^rvs before and after aspirin. AU represents arbitrary units of ALX expression intensity determined by FACS.