Figure 10.

Effect of mNcoA4 on androgen receptor (AR)-mediated or aryl hydrocarbon receptor (AhR)-mediated transactivation in COS cells. COS cells were transiently transfected with expression vectors for NcoA4 and AR (A) or AhR (B). Cells were treated with vehicle (ethanol or n-nonane) or 10 nM dihydrotestosterone or 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin 24 hr after transfection and were harvested 24 hr after treatment. Shown is a representative graph of one of three experiments. Bars represent the mean ± SEM of three replicates. Bars with different letters are statistically different from one another as determined by ANOVA followed by a Fisher's least-significant difference post-hoc test (p<0.05).