Fig. 3.
IEs are generated and amplified during serial-passage culture (model 5). (a) Here we allowed for the generation of new IUs from cells infected with virus alone (CV), producing both virus and new IUs. Model 5 (lines) captured the essential features of passage results of both virus and IE at a fixed m.o.i. of (b) 100 p.f.u. cell−1 and (c) 10 p.f.u. cell−1. Data are p.f.u. (filled symbols) and IE (open symbols) and model results are p.f.u. (solid lines) and IE (dashed lines). The parameter for IE generation was g (0.001) and the other parameters remained unchanged from model 4.