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The maxillary (mx) portion of the neural-crest-derived mesenchyme, normally condensed on the invaginated oral ectodermal (oe) roof in (A), is critically dependent upon Hedgehog signaling, as revealed by the absence of mx in (B) after exposure of the early embryo to cyclopamine. The other arch 1 (a1) crest-derived mesenchyme is relatively normal in appearance. p, hyomandibular pouch. From Eberhart et al. (2006).
