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Mutation of the 4.5S RNA severely attenuates GAS pathogenesis in a mouse bacteraemia model of infection. Shown is a Kaplan–Meier survival plot of groups of 20 mice infected via intraperitoneal injection with 2.5×107 c.f.u. of parental strain MGAS2221 (+vector; WT, black), isogenic mutant 2221Δ4.5S (+vector; MUT, red), or complemented mutant 2221Δ4.5S (+p4.5S; COMP, blue). Significance was tested using the logrank test.
