Fig. 4.
Summary of significant structural abnormalities identified by case-control, voxel-based morphometry studies of OCD. Peak MNI coordinates of decreased and increased grey matter from whole brain VBM studies are shown on axial brain images. The plotted coordinates indicate some agreement with traditional orbitofronto-striatal models of OCD but also a rationale to explore other theoretically unpredicted regions such as parietal areas: (A) areas of increased grey matter and (B) areas of decreased grey matter. R and L markers denote side of brain, numbers denote z dimension of each slice in MNI space.