Table 2.

Significant foci of case-control abnormalities in fMRI studies of OCD from an ALE meta-analysis

Cluster	Volume (mm3)	Weighted centre			Maximum ALE value	ALE maxima and submaxima			Region/approximate BA
		X	Y	Z		X	Y	Z
Activation in OCD patients>activation in healthy controls
1	4912	3.0	22.8	31.0	0.0080	−2	14	34	L anterior cingulate BA 32
					0.0073	0	32	18	L anterior cingulate BA 32
					0.0069	6	28	34	R medial frontal gyrus BA 6
					0.0064	8	18	38	R anterior cingulate BA 32
2	2960	−44.8	29.5	−0.4	0.0094	−46	36	2	L inferior frontal gyrus BA 45
					0.0061	−44	22	−6	L inferior frontal gyrus BA 47
3	1064	22.1	−15.8	−12.9	0.0062	22	−16	−14	R parahippocampal gyrus BA 28
4	888	2.1	−3.8	15.6	0.0066	4	−4	16	R thalamus
5	768	−27.0	−47.9	49.9	0.0078	−28	−48	50	L parietal (precuneus) BA 7
6	704	6.2	−21.1	3.2	0.0074	6	−22	4	R thalamus
7	648	−40.4	−64.2	4.5	0.0069	−42	−64	4	L mid occipital gyrus BA 37
8	640	32.2	10.1	7.8	0.0074	32	10	8	R claustrum
9	592	43.3	21.1	−4.8	0.0059	44	22	−6	R inferior frontal gyrus BA 47
10	440	8.1	10.0	13.8	0.0060	8	10	14	R caudate
11	360	−16.1	31.6	−10.0	0.0058	−16	32	−10	L medial frontal gyrus BA 10
12	320	12.6	42.5	0.6	0.0059	12	42	0	R anterior cingulate BA 32
13	312	−0.6	−44.8	18.1	0.0059	−2	−44	18	L posterior cingulate BA 30
14	304	24.7	20.7	−7.7	0.0057	24	20	−8	R claustrum
15	288	−16.9	12.3	43.8	0.0058	−18	12	44	L medial frontal gyrus BA 32
16	256	25.1	−16.8	54.8	0.0058	24	−18	56	R precentral gyrus BA 6
Activation in healthy controls>activation in OCD patients
1	1920	−26.3	17.9	−2.8	0.0048	−20	16	−6	L putamen
					0.0048	−24	16	−2	L putamen
					0.0044	−34	18	−2	L inferior frontal BA 47
					0.0041	−32	18	10	L insula BA 13
2	1864	−6.2	20.7	36.7	0.0061	−6	22	38	L anterior cingulate BA 32
3	928	5.3	13.6	9.6	0.0071	6	14	10	R caudate
4	624	32.5	47.5	2.6	0.0053	32	48	2	R inferior frontal BA 44
5	496	0	−79.4	−15.7	0.0048	0	−80	−16	R cerebellum
6	280	−24.5	−3.2	−18.4	0.0041	−24	−8	−16	L parahippocampal gyrus/amygdala
					0.0041	−24	2	−20	L uncus BA 28

Abbreviations: L, Left; R, Right; BA, Brodmann area.

Talairach coordinates are reported.