Table 4.

Voxel-based morphometry MRI analyses of OCD

Study	Talairach coordinatesa			Location
	X	Y	Z
Regions of increased grey matter in patients
Kim et al. (2001)	−25	55	6	Left orbitofrontal cortex
	−49	−21	11	Left superior temporal gyrus
	−50	−35	41	Left inferior parietal lobule
	−5	−23	14	Left thalamus
	32	12	−2	Right insula
	54	−59	9	Right middle temporal gyrus
	36	−84	−4	Right inferior occipital cortex
	−1	−1	−6	Bilateral hypothalamus
Pujol et al. (2004)	17	12	0	Right ventral putamen
	−12	−45	−10	Left anterior cerebellum
	−19	13	−4	Left ventral putamen
Valente et al. (2005) b	−22	19	7	Left posterior orbitofrontal cortex and anterior insula
	−31	−23	−19	Left parahippocampal gyrus, uncus, amygdala
	30	−23	−18	Right parahippocamapal and fusiform gyri
Regions of decreased grey matter in patients
Kim et al. (2001)	−40	−64	−34	Left cerebellum
	−14	−49	13	Left cuneus
Pujol et al. (2004)	1	31	39	Right medial frontal gyrus
	−4	33	−19	Left gyrus rectus (medial orbitofrontal cortex)
	−43	−11	8	Left posterior insula
Valente et al. (2005) b	34	−61	35	Right angular and supramarginal gyrus (parietal cortex)
	17	50	16	Right anterior orbitofrontal cortex
	−17	27	33	Left anterior cingulate and medial frontal cortex

^aWhere analyses produced coordinates in MNI space, these coordinates were then converted to Talairach space using the icbm2tal transform (Lancaster et al., 2007).

^bReported coordinates are for the sample including 12 patients, after subjects with co-morbid depression were excluded.