Fig. 4.

The PCST pheromone response network is compact, and, when compared to networks predicted by other methods, it contains higher fraction of genes that are implicated in mating responses, measured by defects in activating a FUS1-lacZ reporter gene (51) and defects in cell cycle arrest and shmoo formation (52). Enrichment P-values were computed by hypergeometric tests using all the genes tested in the respective genetic screen as background. The number above each bar denotes the number of nodes in the network.