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. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: Gastroenterology. 2009 Sep 24;138(1):315–324. doi: 10.1053/j.gastro.2009.09.017

Clearance of a primary infection attenuates the infection kinetics of subsequent infections. A) Maximum HCV RNA concentrations (IU/ml) detected in serum samples obtained during primary and subsequent infections in subjects with sufficient follow-up following the detection of a reinfection. Triangles represent maximum viremia detected in Reinfection – persistent subjects. The maximum viremia in each subject during initial infection and reinfection is connected by a line. Median maximum HCV RNA concentration of reinfections was significantly lower than primary infections (P < 0.001). B) Duration of viremia (days) during primary infections and subsequent infections in Reinfection – cleared subjects. The duration of initial and reinfection viremia in each subject is connected by a line. The duration of viremia during reinfection was significantly lower than in primary infection (P = 0.019).

Clearance of a primary infection attenuates the infection kinetics of subsequent infections. A) Maximum HCV RNA concentrations (IU/ml) detected in serum samples obtained during primary and subsequent infections in subjects with sufficient follow-up following the detection of a reinfection. Triangles represent maximum viremia detected in Reinfection – persistent subjects. The maximum viremia in each subject during initial infection and reinfection is connected by a line. Median maximum HCV RNA concentration of reinfections was significantly lower than primary infections (P < 0.001). B) Duration of viremia (days) during primary infections and subsequent infections in Reinfection – cleared subjects. The duration of initial and reinfection viremia in each subject is connected by a line. The duration of viremia during reinfection was significantly lower than in primary infection (P = 0.019).