TABLE 2.
Immunological parameters in mice exposed to single WBI (Fig. 1) with 0.1 or 0.2 Gy X-rays.
| Parameter | Control | 0.1 Gy | 0.2 Gy |
|---|---|---|---|
| Cytotoxicity (NK cells) [% lysis] | 7.2 | 11.1* ↑ | 11.4* ↑ |
| Expression of FasL by NK cells | 3.5 | 4.9* ↑ | 4.9* ↑ |
| Cytotoxicity (Mϕ) [% lysis] | 29.3 | 40.4* ↑ | 42.1* ↑ |
| Production of NO by Mϕ [μM NO2−/l] | 6.2 | 21.4* ↑ | 20.4* ↑ |
| Production of IFN-γ by NK cells [pg/ml] | 46 | 75* ↑ | 75* ↑ |
| Production of IL-1β by Mϕ [pg/ml] | 584 | 1005* ↑ | 1168* ↑ |
| Production of IL-2 by splenocytes [pg/ml] | 19 | 31* ↑ | 35* ↑ |
| Production of IL-12 by Mϕ [pg/ml] | 400 | 1881* ↑ | 1844* ↑ |
| Production of TNF-α by Mϕ [pg/ml] | 6600 | 8320* ↑ | 9570* ↑ |
The parameters were examined on the 2nd (NK cell-enriched splenocytes – NK-cells) and 3rd (PHA-stimulated splenocytes and IFN-γ and LPS-stimulated peritoneal macrophages – Mϕ) days after single WBI. Control – sham-exposed mice; 0.1 Gy – mice exposed to a single WBI with 0.1 Gy X-rays; 0.2 Gy – mice exposed to a single WBI with 0.2 Gy X-rays.
*
indicates statistically significant (p<0.05) difference from the results obtained in the control group.