TABLE 3.
Immunological parameters in mice exposed to fractionated WBI (10 fractions in total: 0.01 or 0.02 Gy per fraction per day for 5 days per week for 2 weeks; Fig.2) with total doses of 0.1 or 0.2 Gy X-rays.
| Parameter | Control | 0.1 Gy | 0.2 Gy |
|---|---|---|---|
| Cytotoxicity (NK cells) [% lysis] | 7.0 | 11.9* ↑ | 12.3* ↑ |
| Cytotoxicity (Mϕ) [% lysis] | 24.7 | 42.6* ↑ | 42.9* ↑ |
| Production of NO by Mϕ [μM NO2−/l] | 10.7 | 30.7* ↑ | 36.8* ↑ |
| Production of IFN-γ by NK cells [pg/ml] | 43 | 87* ↑ | 89* ↑ |
| Production of IL-1β by Mϕ [pg/ml] | 532 | 768* ↑ | 897* ↑ |
| Production of IL-2 by splenocytes [pg/ml] | 19 | 30* ↑ | 41* ↑ |
| Production of IL-12 by Mϕ [pg/ml] | 399 | 2342* ↑ | 2898* ↑ |
| Production of TNF-α by Mϕ [pg/ml] | 6875 | 33783* ↑ | 44810* ↑ |
The parameters were examined on the 3rd (PHA-stimulated splenocytes), 4th (NK cell-enriched splenocytes – NK cells) and 5th (IFN-γ- and LPS-stimulated peritoneal macrophages – Mϕ) days after fractionated WBI. Control – sham-exposed mice; 0.1 Gy – mice exposed to total dose of 0.1 Gy X-rays; 0.2 Gy – mice exposed to total dose of 0.2 Gy X-rays.
*
indicates statistically significant (p<0.05) difference from the results obtained in the control group.