Fig. 2.

(Upper) 3D maps show areas where regional brain volumes were significantly associated with BMI in healthy elderly subjects (n = 206). (Lower) In the significant areas, the regression coefficients (unstandardized beta values or “slopes”) are shown at each voxel. These represent the estimated degree of tissue excess or deficit at each voxel (in cubic millimeters relative to the template) for each unit gain in body mass index, after statistically controlling for effects of age and sex, on brain structure. Images are displayed in radiological convention (left side of the brain shown on the right) and are displayed over the MDT.