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. 2010 Apr 19;107(18):8434–8439. doi: 10.1073/pnas.0912690107

Fig. 2.

Fig. 2.

Dentate granule cells in fluoxetine-treated mice show immature-like natures. (A) Left, c-Fos-like immunoreactivity in GC layer after foot shocks. Right, quantitative data showing the number of c-Fos-positive cells in mice in home cages and after foot shocks (n = 4 each). Fluoxetine strongly reduced foot shock-induced c-Fos expression (P = 0.0286). (Scale bar, 200 μm.) (B) Sample recordings of GC spikes (Upper) evoked by depolarizing currents (Lower). (Scale bars: 100 ms, 40 pA, and 50 mV.) (C) Left, the minimal current intensity required to evoke a single spike is smaller in fluoxetine-treated GCs (CNT, n = 31 cells; FLX, n = 35 cells; P = 0.0099). Right, no significant difference in input resistance. (D) Left, TTX (1 μM) completely blocked spikes in control cells. Right, TTX-resistant component (arrow) in fluoxetine-treated cells was blocked by Ni2+ (50 μM). The magnitude of injected currents was 140 pA (CNT) and 100 pA (FLX). (Scale bars: 50 ms, 50 mV (Top), and 20 mV (Middle and Bottom). Data are presented as mean ± SEM.