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. 2010 Apr 16;107(18):8422–8427. doi: 10.1073/pnas.0911838107

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Fig. 2. — Nestin-cre;Smo^f/- or Nestin-cre;SmoM2 mutants exhibit, respectively, reduced or augmented VZ progenitor proliferation and GABAergic interneuron expansion. (A) Nestin-cre activity is detected in almost all neural cells throughout the cerebellum, as indicated by whole-mount and sectioned view of X-gal staining in E13.5 Nestin-cre;R26R embryo; however, Nestin-cre;SmoM2 mutants preferentially display enhanced Shh signaling in the cerebellar VZ. (B) BrdU proliferation, CyclinD1, Pax2, and Lhx1/5 immunohistochemical analyses on WT, Nestin-cre;Smo^f/-, and Nestin-cre;SmoM2 mutants. Red boxes represent higher magnifications of medial and lateral cerebellar regions in adjacent panels. (C) Quantifications of marker stainings in WT, Nestin-cre;Smo^f/-, and Nestin-cre;SmoM2 mutants. CB, cerebellum.