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. 2010 Apr 19;107(18):8316–8321. doi: 10.1073/pnas.0914496107

Fig. 1.

Fig. 1.

Diminished lymphocyte development in older c-Cbl−/− mice. (A) Absolute numbers of CD19+ B cells of the BM were determined as average per animal (two tibia and fibula) at indicated weeks of age. Each group contains n = 5 mice. Data are representative of five independent experiments. Data are presented as mean ± SEM. *, P values <0.05. (B) FACS plots indicating relative frequencies of B cells at 4 (Upper) and 24 weeks (Lower) of age. Data are representative of 10 independent experiments. (C) Absolute numbers of thymocytes at indicated weeks of age. Each group contains n = 5 mice. Data are representative of 10 independent experiments. Data are presented as mean ± SEM. *, P values <0.05. (D) Analysis of thymic T cell development at 4 (Upper) and 24 weeks of age (Lower) in c-Cbl−/− mice.