Fig. 2.

drag-1 functions at the ligand-receptor level in the Sma/Mab pathway to regulate body size. (A) A simplified schematic of the Sma/Mab pathway (see text for details). (B) Body length of wild-type (N2) and various mutant worms at 96 hours post-plating (see Materials and methods). Similar results were observed using worms at 24, 48 and 72 hours post-plating (data not shown). drag-1(jj4); lon-2(e678) and drag-1(jj4); dbl-1(ctIs40) worms show significantly different body length compared with lon-2(e678) and dbl-1(ctIs40) worms, respectively. Error bars represent 95% confidence intervals for the mean body length. The significance of difference between double mutants and the corresponding single mutants was statistically analyzed via Student's t-test. ***, P<0.0001.