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. 2010 Jul 15;137(14):2417–2426. doi: 10.1242/dev.047993

Fig. 3.

Fig. 3.

kuz is required in neurons. (A-F) Stage 16 embryos were stained with a mAb to FasII (1D4). Anterior is up. (A) A wild-type embryo stained with mAb 1D4. (B) Ipsilateral axons from the medial and intermediate fascicles aberrantly cross the midline in kuz mutants (arrow with asterisk). (C,E) Midline expression of UASkuzHA using a slitGal4 driver does not rescue the kuz phenotype. One hundred percent of kuz mutant embryos with midline kuz overexpression show ectopic midline crossing of FasII-positive axons in greater than half of all segments (107 out of 135 or 79% of segments show ectopic crossing, n=15 embryos). (D,F) Pan-neural expression of UASkuzHA provides complete rescue of the kuz mutant phenotype (0 out of 144 segments show ectopic crossing, n=16 embryos).