Fig. 9.

Model of Kuz function in Slit/Robo repulsion. Our data suggest a model for Kuz function in the Slit/Robo pathway in which Slit binding to the Robo receptor results in cleavage of Robo by Kuz. Release of the Robo ectodomain could cause a conformational change in the remainder of the membrane-bound Robo receptor that strengthens its interaction with the Dock and recruits Sos to the plasma membrane. Sos is then properly localized to the plasma membrane, where it activates Rac to promote growth cone repulsion.