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Summary of optimum surface behavior for an implanted neural probe. (A) Surface of encapsulation and insulation material: adsorption of proteins and adhesion of fibroblast for good incorporation into the tissue, no reaction of macrophages. (B) Surface without electrodes: good contact to neurons and glial cells, no reaction of macrophages. (C) Surface of electrodes: attraction and good contact to neurons, no adhesion of fibroblasts, no macrophage reaction.
