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. 2010 Mar 9;18(6):1111–1122. doi: 10.1038/mt.2010.28

Figure 4.

Figure 4

Average differences in SGN densities between injected and noninjected cochleae for the basal, middle, and apical turns of 1-week deafened GPs. SGN survival with respect to the contralateral cochlea (positive difference) or loss (negative difference) was determined for each deafened experimental group (groups 1–4). In the basal turn, there was significantly greater SGN survival in cochleae injected with Ad-GFP-NT in the scala media compared to all other groups. There was also significant loss of SGNs in cochleae injected with Ad-GFP in the scala media compared to the scala tympani. In the middle and apical turns, there were significant losses of SGN in cochleae injected with Ad-GFP-NT into the scala media compared to the scala tympani (†P < 0.05 for one-way analysis of variance group comparisons; *P < 0.05 for injected versus noninjected cochlea t-test comparisons). Error bars indicate the standard error of the mean (n = 4–7 GPs per point). GFP, green fluorescent protein; GP, guinea-pig; SGN, spiral ganglion neuron; SM, scala media; ST, scala tympani.