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. 2010 Mar 30;18(6):1085–1093. doi: 10.1038/mt.2010.46

Figure 5.

Figure 5

Long-term regulation of retinal function in RPE65-deficient dogs following subretinal injection of the AAV2/4TetOn.rpe65 vector. Affected dogs (a) A4 and (b) A5 before injection and at different time points postinjection, in the ON and OFF states. The b-wave amplitudes of the ERG max. (scotopic) of the treated and untreated eyes were measured and reported in the graphs. Gray, treated eye; black, untreated contralateral eye. The ON state was obtained upon oral administration of Dox, whereas the OFF state was obtained in the absence of Dox. bi, before injection; ERG, electroretinography; mpi, months postinjection.