TABLE 3.
Morphological and metabolic variable summaries by treatment category in ∼10-week-old fasted wild-type mice that received continuous subcutaneous infusion of either vehicle or leptin at a physiological dose
| Saline | Group |
Highest leptin† | |||
|---|---|---|---|---|---|
| All leptin* | |||||
| n = 8 | n = 24 | n = 8 | P§ | P‖ | |
| Body mass (g) | 19.3 ± 1.0 | 19.4 ± 0.8 | 19.4 ± 0.6 | 0.81 | 0.77 |
| LBM (g) | 16.0 ± 0.8 | 16.2 ± 0.7 | 16.3 ± 0.5 | 0.47 | 0.32 |
| FM (g) | 1.6 ± 0.4 | 1.5 ± 0.4 | 1.4 ± 0.3 | 0.78 | 0.29 |
| % Body fat | 8.0 ± 1.4 | 7.7 ± 1.9 | 6.9 ± 1.6 | 0.67 | 0.17 |
| Leptin (ng/ml) | 0.3 ± 0.3 | 7.1 ± 4.5 | 11.9 ± 3.2 | 0.0002 | 0.00001 |
| Activity (counts/min) | 55.4 ± 14.7 | 44.2 ± 16.2 | 40.4 ± 9.7 | 0.09 | 0.03 |
| RER | 0.73 ± 0.005 | 0.73 ± 0.007 | 0.73 ± 0.005 | 0.62 | 1.0 |
| 24-h mean EE (cal/min) | 6.43 ± 0.47 | 7.14 ± 0.53 | 7.37 ± 0.23 | 0.002 | 0.0002 |
Data are means ± SD. n = 32.
*Group includes animals receiving 50, 100, and 200 ng leptin/h.
†Group includes animals receiving only 200 ng leptin/h.
§Significance of comparison between saline and all leptin-treated mice.
‖Significance of comparison between saline and mice receiving 200 ng leptin/h.