FIG. 7.

Effects of GABA on the membrane potential of human β-cells. Membrane potential was recorded in noninfected cells in the perforated-patch configuration, using the Cl⁻-impermeable antibiotic gramicidin as the perforating agent. Recordings were made at 6 mmol/l extracellular glucose. A: Application of GABA (100 μmol/l, indicated by bars) to a β-cell in the absence (left) or presence (right) of 50 μmol/l SR-95531. B: Application of 10 μmol/l GABA (bar) to an electrically active β-cell.