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. 2010 Mar 18;59(7):1809–1816. doi: 10.2337/db09-1056

FIG. 3.

FIG. 3.

SERPINA3K decreased CTGF mRNA levels in the diabetic retinas and in high-glucose–treated cells. A: Ad-SA3K and Ad-LacZ were injected intravitreally into the eyes of diabetic rats, and the retinas were dissected 4 weeks after the injection. B and C: rMC-1 cells (B) and HTERT RPE-1 cells (C) were exposed to low-glucose and high-glucose media for 16 h, with and without 100 nmol/l SERPINA3K or BSA. Real-time RT-PCR was performed to quantify relative mRNA levels of CTGF in the retinas (A), rMC-1 cells (B), and RPE cells (C). Values are means ± SD, n = 3. *P < 0.05.