FIG. 4.
Comparison of the mutation profiles in H-HCA (67 transversions and transitions, A), MODY3 (229 transversions and transitions, B), and TP53-mutated lung cancers (311 transversions and transitions, C) and smokers (26) (D). Repartitioning of transition and transversion mutations between the transcribed and the nontranscribed strands in H-HCA. Black and white histograms indicate the number of nucleotide substitutions on the nontranscribed and the transcribed strand, respectively. *Significant (P = 0.01) elevation in G-to-T transversions on the nontranscribed strand.