Table 3. Comparative genomic analysis between Clonorchis sinensis, Opisthorchis viverrini, other parasitic trematodes and selected eukaryotic (model) organisms.
| Clonorchis sinensis sequences (n = 50,769) | Opisthorchis viverrini sequences (n = 61,417) | |||||
| with homology (%) | with homology (%) | |||||
| Predicted proteins similara to those in: | <1E−05 | <1E−15 | <1E−30 | <1E−05 | <1E−15 | <1E−30 |
| Clonorchis sinensis | 29,995 (48.84) | 22,216 (36.17) | 16,324 (26.58) | |||
| Opisthorchis viverrini | 27,103 (53.38) | 21,036 (41.43) | 15,796 (31.11) | |||
| NCBI non-redundant database | 16,782 (33.06) | 12,164 (23.96) | 7,974 (15.71) | 19,126 (31.14) | 13,664 (22.25) | 9,093 (14.81) |
| Fasciola hepatica | 15,725 (30.97) | 10,580 (20.84) | 6,700 (13.20) | 17,495 (28.49) | 11,572 (18.84) | 7,186 (11.70) |
| Schistosoma mansoni | 15,229 (30.00) | 11,033 (21.73) | 7,465 (14.70) | 16,736 (27.25) | 11,897 (19.37) | 8,095 (13.18) |
| Schistosoma japonicum | 14,526 (28.61) | 10,159 (20.01) | 6,429 (12.66) | 15,982 (26.02) | 11,116 (18.10) | 7,083 (11.53) |
| Mus musculus | 10,177 (20.05) | 6,628 (13.06) | 3,890 (7.66) | 11,238 (18.30) | 7,246 (11.80) | 4,203 (6.84) |
| Homo sapiens | 10,164 (20.02) | 6,591 (12.98) | 3,890 (7.66) | 11,206 (18.25) | 7,259 (11.82) | 4,213 (6.86) |
| Danio rerio | 10,000 (19.70) | 6,386 (12.58) | 3,744 (7.37) | 11,100 (18.07) | 7,043 (11.47) | 4,042 (6.58) |
| Gallus gallus | 9,737 (19.18) | 6,187 (12.19) | 3,613 (7.12) | 10,718 (17.45) | 6,795 (11.06) | 3,889 (6.33) |
| Xenopus tropicalis | 9,642 (18.99) | 6,105 (12.03) | 3,505 (6.90) | 10,716 (17.45) | 6,683 (10.88) | 3,823 (6.22) |
| Drosophila melanogaster | 9,032 (17.79) | 5,676 (11.18) | 3,292 (6.48) | 10,092 (16.43) | 6,251 (10.18) | 3,583 (5.83) |
| Caenorhabditis elegans | 8,029 (15.81) | 4,847 (9.55) | 2,771 (5.46) | 8,951 (14.57) | 5,367 (8.74) | 2,974 (4.84) |
| Saccharomyces cerevisiae | 4,509 (8.88) | 2,371 (4.67) | 1,266 (2.49) | 5,194 (8.46) | 2,655 (4.32) | 1,397 (2.27) |
a
All amino acid sequences conceptually translated from ORF-enriched sequence data were searched against protein databases using BLASTx employing permissive (E-value of <1E−05), moderate (E-value of <1E−15) and stringent (E-value of <1E−30) search strategies.