Table 4. Comparative genomic analysis between or among Clonorchis sinensis, Opisthorchis viverrini, Fasciola hepatica, Schistosoma mansoni, S. japonicum (blood flukes) and selected mammals.

	Clonorchis sinensis sequences			Opisthorchis viverrini sequences
	(n = 50,769) with homology (%)			(n = 61,417) with homology (%)
Proteins predicted to be similara to those in:	1E−05	1E−15	1E−30	1E−05	1E−15	1E−30
S. japonicum and S. mansoni	13,254	9,325	5,940	14,438	10,067	6,459
	(26.10)	(18.37)	(11.70)	(23.51)	(16.39)	(10.52)
F. hepatica and S. japonicum and S. mansoni	11,134	7,403	4,508	12,167	7,994	4,762
	(21.93)	(14.58)	(8.88)	(19.81)	(13.02)	(7.75)
O. viverrini and F. hepatica and S. japonicum and S. mansoni	10,875	7,164	4,320
	(21.42)	(14.11)	(8.51)
C. sinensis and F. hepatica and S. japonicum and S. mansoni				11,780	7,660	4,529
				(19.18)	(12.47)	(7.37)
Homo sapiens and Mus musculus	9,954	6,475	3,829	10,983	7,116	4,143
	(19.61)	(12.75)	(7.54)	(17.88)	(11.59)	(6.75)
Eukaryotic model organismsb	3,434	1,732	906	3,753	1,856	947
	(6.76)	(3.41)	(1.78)	(6.11)	(3.02)	(1.54)

^aORF-enriched sequence data were searched against protein databases by BLASTx using permissive (E-value of <1E⁻⁰⁵), moderate (E-value of <1E⁻¹⁵) and stringent (E-value of <1E⁻³⁰) search strategies.

^bProteins that were homologous to model organisms assessed in Table 3.