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The box and whisker plot shows the median value and 10-90 percentiles of biomarkers, ESR1 and 14-3-3-σ, measured in the serum of the individuals in each of the three study groups: Healthy Controls (HC); Disease-Free Breast Cancer (DFBC); and Metastatic Breast Cancer (MBC). 14-3-3-σ values significantly differed between the DFBC and MBC groups (Dunn test, P > 0.0001) and between each of these and the HC group (P < 0.001).
