Table 1.
51 significantly deregulated miRNAs sorted by their AUC value.
| miRNA | median melanoma | median normal | fold change | wmw adjp | ttest adjp | limma adjp | AUC |
|---|---|---|---|---|---|---|---|
| hsa-miR-452* | 189.7 | 633.3 | 0.3 | 0 | 0.00046 | 0 | 0.99 |
| hsa-miR-216a | 89.1 | 197.3 | 0.5 | 0.000001 | 1.7E-05 | 0.000039 | 0.98 |
| hsa-miR-186 | 206.5 | 26.2 | 7.9 | 0.000001 | 0 | 0 | 0.97 |
| hsa-let-7d* | 178.6 | 37.7 | 4.7 | 0.000001 | 0 | 0 | 0.96 |
| hsa-miR-17* | 433.5 | 941.8 | 0.5 | 0.000001 | 0 | 0 | 0.96 |
| hsa-miR-646 | 150.9 | 350.6 | 0.4 | 0.000001 | 0.00038 | 0 | 0.96 |
| hsa-miR-217 | 86.3 | 183.8 | 0.5 | 0.000001 | 0.00055 | 0.000003 | 0.96 |
| hsa-miR-621 | 178.6 | 486.7 | 0.4 | 0.000001 | 0.00011 | 0 | 0.95 |
| hsa-miR-517* | 109.9 | 230.8 | 0.5 | 0.000001 | 0.00022 | 0 | 0.95 |
| hsa-miR-99a | 217.3 | 85 | 2.6 | 0.000002 | 0 | 0 | 0.95 |
| hsa-miR-664 | 557 | 173 | 3.2 | 0.000002 | 0 | 0 | 0.94 |
| hsa-miR-593* | 175.4 | 356.7 | 0.5 | 0.000002 | 0.00027 | 0 | 0.94 |
| hsa-miR-18a* | 397.4 | 135 | 2.9 | 0.000002 | 0 | 0 | 0.94 |
| hsa-miR-145 | 358 | 94.6 | 3.8 | 0.000002 | 0 | 0 | 0.94 |
| hsa-miR-1280 | 6779.6 | 2676.2 | 2.5 | 0.000002 | 0 | 0 | 0.93 |
| hsa-let-7i* | 122.8 | 281.4 | 0.4 | 0.000003 | 0.00045 | 0 | 0.93 |
| hsa-miR-422a | 279.2 | 104.5 | 2.7 | 0.000004 | 0 | 0 | 0.92 |
| hsa-miR-330-3p | 213.1 | 443.2 | 0.5 | 0.000004 | 0.00052 | 0 | 0.92 |
| hsa-miR-767-5p | 107.1 | 232.4 | 0.5 | 0.000004 | 0.00022 | 0.000001 | 0.92 |
| hsa-miR-183* | 195.9 | 87.7 | 2.2 | 0.000004 | 1E-06 | 0 | 0.92 |
| hsa-miR-1249 | 144.8 | 46.1 | 3.1 | 0.000004 | 0 | 0.000004 | 0.92 |
| hsa-miR-20b | 2163.5 | 5665.8 | 0.4 | 0.000004 | 2E-06 | 0.000001 | 0.92 |
| hsa-miR-509-3-5p | 157 | 371.4 | 0.4 | 0.000004 | 0.00046 | 0 | 0.92 |
| hsa-miR-519b-5p | 72.5 | 155.1 | 0.5 | 0.000004 | 2.9E-05 | 0.000398 | 0.92 |
| hsa-miR-362-3p | 449 | 167.8 | 2.7 | 0.000004 | 4E-06 | 0 | 0.92 |
| hsa-miR-501-5p | 106.5 | 27.8 | 3.8 | 0.000004 | 0 | 0.000002 | 0.92 |
| hsa-miR-378* | 103.7 | 29.4 | 3.5 | 0.000004 | 0 | 0.000002 | 0.92 |
| hsa-miR-365 | 160.5 | 65.1 | 2.5 | 0.000006 | 0 | 0.000001 | 0.91 |
| hsa-miR-151-3p | 999 | 422.6 | 2.4 | 0.000006 | 1E-06 | 0 | 0.91 |
| hsa-miR-342-5p | 196.8 | 92.1 | 2.1 | 0.000008 | 1E-06 | 0.000003 | 0.91 |
| hsa-miR-328 | 175.4 | 32.3 | 5.4 | 0.000008 | 0 | 0.000001 | 0.9 |
| hsa-miR-181a-2* | 154.8 | 64.7 | 2.4 | 0.000016 | 4E-06 | 0.000004 | 0.89 |
| hsa-miR-518e* | 88.1 | 196.4 | 0.4 | 0.000019 | 0.00045 | 0.000586 | 0.89 |
| hsa-miR-362-5p | 245.4 | 119.5 | 2.1 | 0.000023 | 8E-06 | 0.000001 | 0.88 |
| hsa-miR-584 | 198.2 | 46.9 | 4.2 | 0.000023 | 1.5E-05 | 0.000008 | 0.88 |
| hsa-miR-550* | 808.5 | 313.8 | 2.6 | 0.000024 | 2.6E-05 | 0.000003 | 0.88 |
| hsa-miR-30a | 682.9 | 334.8 | 2 | 0.000027 | 4E-06 | 0.000002 | 0.88 |
| hsa-miR-221* | 54.3 | 113.8 | 0.5 | 0.000029 | 0.00011 | 0.00039 | 0.88 |
| hsa-miR-361-3p | 263.9 | 99 | 2.7 | 0.000033 | 2E-06 | 0.000003 | 0.88 |
| hsa-miR-625 | 185.8 | 63.3 | 2.9 | 0.000037 | 1.7E-05 | 0.000038 | 0.87 |
| hsa-miR-146a | 326.8 | 161.8 | 2 | 0.000037 | 3.9E-05 | 0.000003 | 0.87 |
| hsa-miR-214 | 172.3 | 383.4 | 0.4 | 0.000042 | 0.00038 | 0.000001 | 0.87 |
| hsa-miR-106b | 8639.8 | 18881 | 0.5 | 0.000044 | 8.5E-05 | 0.000019 | 0.87 |
| hsa-miR-18a | 1060.8 | 2560 | 0.4 | 0.000053 | 0.00074 | 0.000013 | 0.86 |
| hsa-miR-30e* | 101.7 | 47.8 | 2.1 | 0.000022 | 5E-06 | 0.000098 | 0.86 |
| hsa-miR-125a-5p | 370.8 | 147.4 | 2.5 | 0.000059 | 3.3E-05 | 0.000001 | 0.86 |
| hsa-miR-142-3p | 105.3 | 2 | 53 | 0.000082 | 1.7E-05 | 0.000009 | 0.85 |
| hsa-miR-107 | 725.8 | 1938.9 | 0.4 | 0.000092 | 0.00097 | 0.000034 | 0.85 |
| hsa-miR-20a | 3254.3 | 7282.8 | 0.4 | 0.000134 | 0.00016 | 0.000062 | 0.84 |
| hsa-miR-22* | 117.7 | 45 | 2.6 | 0.000193 | 3.7E-05 | 0.000138 | 0.83 |
| hsa-miR-199a-5p | 551.4 | 267.9 | 2.1 | 0.000201 | 0.00066 | 0.000042 | 0.83 |
adjp = adjusted p-value, AUC = area under the receiver operator charcteristic curve, wmw = Wilcoxon Mann-Whitney test, limma= linear model with p-values computed by an empirical bayes approach