Skip to main content
. Author manuscript; available in PMC: 2010 Jun 22.
Published in final edited form as: Am J Transplant. 2010 Mar 26;10(5):1210–1220. doi: 10.1111/j.1600-6143.2010.03089.x

Figure 8. Frequencies of alloreactive IFN-γ-producing splenocytes and CD8+ memory T cells in CD27−/− and wild-type (WT) B6 recipients of bm1 allografts.

Figure 8

(A) The frequency of alloreactive IFN-γ-producing splenocytes was significantly decreased in CD27−/−recipients compared to WT recipients. (B) Alloreactive CD8+ T cells are the main source of IFN-γproduction. Frequency of CD8+ IFN-γ-producing splenocytes is significantly decreased in CD27−/− animals. (C) The frequency of CD8+ effector-memory and CD8+ central-memory cells as well as the overall CD8+ memory T-cell pool was significantly decreased in CD27−/− animals when compared to WT animals. Data are representative of two independent experiments (n = 3/3 each). ELISPOT data are shown as the mean of quintuplicate results in each experiment. *p < 0.05; **p < 0.01.