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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer. 2010 Jun 1;116(11 Suppl):2806–2814. doi: 10.1002/cncr.25167

Figure 2. Effects Of EP Receptor Agonists And Antagonists On Invasion Of Breast Cancer Cells.

Figure 2

Figure 2A. Effect of PGE2 and EP4 Agonist PGE1-Alcohol on Invasion. PGE2 and the EP4 agonist PGE1-alcohol induced significantly increased invasion of SUM149 cells but had no effect on invasion of MDA-MB-231 cells.

Figure 2B. Effect Of GW627368X On Invasion. GW627368X, induced a significant dose dependent inhibition of invasion beginning at the lowest concentration of 0.1 μM, compared to the inhibition of invasion by MDA-MB-231 by GW627368X at higher concentrations.

Figure 2C. Effect Of EP4 shRNA On Invasion. The presence of EP4 shRNA in SUM149/Clone 1 abolished 95% of invasion.

Figure 2D. Effect Of Sulprostone On Invasion. Sulprostone inhibited invasion by SUM149 cells in a dose dependent manner starting at 0.1 μM, with no effect of this agent on invasion by MDA-MB-231 cells.