Table 1.

Cav-1 interactions with viral proteins

Virus family (-viridae)	Virus	Protein	Protein function	Type of interaction with protein partner	Type of interaction with Cav-1	Reference
Retro	HIV-1	gp41	Transmembrane, fusion	Binding to CBD in HIV-1, but not HIV-2 or SIV	Binding to CSD*	(Benferhat et al., 2008; Hovanessian et al., 2004)
	HIV-1	gp41	Transmembrane, fusion	Binding to six-helix bundle	Binding to CSD	(Huang et al., 2007)
	HIV-1	Not known		Not known	Cav-1 membrane insertion domain	(Llano et al., 2002)
	MLV-amphotropic, ecotropic	MA-Gag	Matrix, associates with membranes, link between capsid, plasma membrane, and viral membrane proteins	Binding mediated by a CBD in MA, interaction locates MA to lipid rafts domains in PM	Interaction with CSD*†	(Beer and Wirth, 2004; Yu et al., 2006)
Corona	SARS	ORF3a	Not known, Functioning in Golgi localization?	Binding to several CBDs	Not known, interaction with CSD likely	(Padhan et al., 2007)
Orthomyxo	Influenza A virus human	M2	Early phase: Ion channel, viroporin Late Phase: matrix, virus assembly and budding	Binding. Protein regions presumably CBD aa47-55	Binding to CSD*† Binding to CSD‡	This investigation Zou et al. 2009
	Influenza A virus human	HA	Receptor binding	Colocalization in perinuclear regions		(Scheiffele et al., 1998)
Paramyxo	RSV	?	?	Colocalization with internal viral filaments, colocalization at lipid rafts	Binding not specified, redistribution of Cav-1 after phosphorylation	(Brown et al., 2002; Brown, Rixon, and Sugrue, 2002; McDonald et al., 2004)
Reo	Rotavirus	NSP4	Ion channel formation, ER and caveolae localization, important for morphogenesis	Binding aa114-135 (enterotoxic peptide) amphipatic helix at the C-terminus	Binding and colocalization, 2 independent binding sites at the N-terminus (aa2-22)and C-terminus (aa161-178) identified, influence on localization or transport?	(Mir et al., 2007; Parr et al., 2006; Storey et al., 2007)

*Pull-down experiments with biotinylated CBD-peptides

^†Co-immunoprecipitation

^‡ ELISA